CSF-ctDNA was detected in 59% of cases and showed high concordance (84%) with tumor mutations. Lower variant allelic frequency in CSF-ctDNA was associated with significantly worse survival outcomes.
A CSF leak within the spinal column is the most common identifiable cause of spontaneous intracranial hypotension. 3 The mechanism underlying headache and neurologic manifestations is presumed to be ...
Sequencing circulating tumor cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) improved diagnosis, decision-making, and clinical care in pediatric and adolescent and young adult (AYA) patients with ...
Researchers found that individuals have distinct baseline levels of brain-derived proteins in cerebrospinal fluid, masking ...
Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022 Effective diagnosis, prognostication, ...
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