A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

The way the body ages could be more resilient than previously thought, a new study suggests. Published in the Journal of the American Chemical Society, the work by researchers at King's College London ...

PacBio launched CiFi, a method combining 3C and HiFi long-read sequencing to generate chromosome scale, haplotype resolved ...

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact within these droplet-like structures. The findings connect molecular ...

Chromatin bridges are DNA strings that link anaphase poles or daughter nuclei and are associated with carcinogenesis. In response to chromatin bridges, mammalian cells delay abscission by activating ...

A novel, freely available AI tool has cut the time it takes to determine chromatin structure from days to minutes. The 3D structure of DNA is important for controlling cell-specific gene expression ...

Single-cell analyses have emerged as powerful tools for studying cellular heterogeneity and gene regulation. Single-cell chromatin accessibility sequencing (scCAS) is a key technology that enables the ...