In the human liver, nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A in response to a wide variety of drugs and plays a critical role in mediating drug-drug interactions. In June 14 ...

Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and comprise the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Mestinon (pyridostigmine) is a prescription drug used to treat myasthenia gravis. This drug can interact with other medications. For example, Mestinon can interact with corticosteroids and ...

Xgeva (denosumab) is a brand-name subcutaneous injection prescribed for certain bone-related problems. Xgeva may interact with some other drugs and certain vaccines. Examples include cinacalcet ...

There’s no doubt that large language models and generative AI tools have taken the world by storm. Their ability to create, ...

Wellbutrin can interact with several drugs, including other antidepressants, stimulants, and certain diabetes medications. These interactions can increase the risk of side effects or reduce the ...