Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 ...
Scientists reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands. Through an international collaboration, scientists at St. Jude ...
Structure Therapeutics (GPCR) just moved its obesity pipeline up a gear by kicking off a first in human Phase 1 trial for ACCG-2671, its oral amylin receptor agonist targeting metabolic disease. See ...
Scientists from The Scripps Research Institute have determined the structure of a new neurological receptor, A2A adenosine receptor, from within a larger group of four GPCRs that play an essential ...
In December 2025, Structure shared topline data from the ACCESS clinical program of aleniglipron, including 36-week data from the core Phase 2b ACCESS study and the ongoing exploratory ACCESS II study ...
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