Metabolic dysfunction-associated steatohepatitis (MASLD) is a liver disease with complex pathogenesis, characterized by abnormal lipid accumulation within hepatocytes, inflammation, and fibrosis. Its ...

Research, headed by teams at Trinity College Dublin and University College Dublin, has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body’s ...

In 1980, Ludwig and colleagues described the histologic features of a newly identified chronic liver condition referred to as nonalcoholic steatohepatitis (NASH) and noted that the majority of the ...

Subtle cellular interactions, especially involving immune cells and lipid metabolism, are crucial in MASH progression. A spatially resolved, multi-omics atlas of MASLD was developed, integrating ...

Lipid membranes, which form the outer layer of cells, can be engineered to influence cellular functions. For example, adjusting the permeability of the membrane can improve drug delivery. Adding ...

Elevated deoxycholic acid, triacylglycerols, ceramides, and phospholipids were identified in MASH patients, suggesting a noninvasive diagnostic potential. The study used untargeted lipidomic analysis ...

A Ludwig Cancer Research study has identified a key mechanism by which advanced ovarian cancers suppress anti-tumor immune responses and resist immunotherapies. Led by Ludwig Princeton's Lydia Lynch ...