These findings are important as they show that affected muscles in an ALS mouse model remain receptive to reinnervation by healthy engrafted motor neurons, even until the late stages of the disease.

A research group conducted experiments using aged mice to demonstrate that muscle denervation at the neuromuscular junction (NMJ, *1) could be appreciably offset by an NMJ formation-enhancing ...

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis. The loss of function of an important gene, C9orf72, may ...

“Instead of inserting the corrected piece of information, we used CRISPR to cut DNA in two strategic places,” study coauthor Dwi Kemaladewi, a research fellow at the Hospital for Sick Children (Sick ...

A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease. An intervention, ...

MIT scientists find that motor neuron growth increased significantly over 5 days in response to biochemical (left) and mechanical (right) signals related to exercise. The green ball represents cluster ...

Scientists have traced connectivity between neurons to identify how the brain communicates with the spinal cord. A new brain map visualizes the connections between the brain and spinal cord at the ...

You may already be familiar with ALS, especially if you took part in the viral ice bucket challenge to raise awareness of the condition back in 2014. Now the disease, which currently has no cure, is ...

As people grow older, many notice that their balance is not as steady as it used to be. Walking may become slower, climbing ...

The obturator nerve is a large, multibranched nerve that travels through your pelvis to your inner thigh. This nerve helps you feel sensations like temperature and pain in your lower limbs. It also ...