Aldose reductase, a key enzyme in the polyol pathway, catalyses the conversion of glucose to sorbitol, a process that becomes particularly problematic in hyperglycaemic conditions. Excessive flux ...
In the Phase 3 BRUIN CLL-313 study, treatment with pirtobrutinib demonstrated a highly statistically significant and clinically meaningful improvement in progression-free survival versus bendamustine ...
U.S. FDA Approves Jaypirca™ (pirtobrutinib), the First and Only Non-Covalent (Reversible) BTK Inhibitor, for Adult Patients with Relapsed or Refractory Mantle Cell Lymphoma After at Least Two Lines of ...
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