The P73 gene is a homologue of the P53 tumor suppressor. Owing to its structural similarity with p53, p73 was originally considered to have tumor suppressor function. However, the discovery of ...

The current view holds that the prominent cortical loss and hydrocephalus of global p73−/− mice are solely a consequence of unopposed apoptosis of mature postmitotic neurons occurring in the weeks and ...

The key to discovering better treatments for chronic lung diseases sits with the p73 gene, scientists believe. They found that this gene is the master regulator of a cell type that is responsible for ...

Healthy aging relies on proper function of the transcription factor p53. Known as “guardian of the genome,” this protein regulates key physiological events such as the cell cycle, DNA repair, and ...

The protein p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or ...

Celltrion announced on June 11 that it presented preclinical results for its antibody-drug conjugate (ADC) new drug candidate, 'CT-P73', at the ongoing 'World ADC Asia Summit' held at the Grand Hyatt ...

Ki-67 is a Luminal B marker that identifies a high-risk subgroup in hormone receptor positive and node negative breast cancer No significant financial relationships to disclose. This is an ASCO ...

Singapore, 26 June 2015 - A team of researchers at National Cancer Centre Singapore (NCCS) and Singapore General Hospital (SGH) has determined dual functionality gene p73, in both the promotion and ...

The protein p53 suppresses tumor development by potently inducing tumor cell death, making it an obvious target for anticancer therapeutics. However, this therapeutic approach is confounded by the ...