Bitter taste receptors, also known as TAS2Rs, are a distinct family of G protein-coupled receptors (GPCRs) originally recognised for their role in oral bitter taste perception. Recent research has ...

Illustration of bitter taste receptor function in keratinocytes. On the left, harmful substances enter skin cells, leading to cellular damage. On the right, bitter taste receptors located in the ...

Researchers have uncovered the structure of a known, widespread human taste receptor, which may help scientists understand the role it plays outside the tongue. “What we found was totally unexpected,” ...

Scientists at St. Jude Children's Research Hospital used structural biology approaches to gain insight into how sweet taste receptors detect sweeteners. Sweet taste receptors are proteins in taste ...

Past studies have shown that the human sweet taste receptor conveys sweet perception in the mouth and may help regulate glucose metabolism throughout the body. At the same time, the anti-inflammatory ...

Cryo-EM map of the human sweet taste receptor (blue and green) changing shape as it binds a molecule that tastes sweet (red and green). NEW YORK — Our attraction to sugar has grown to an unhealthy ...

A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even ...

The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption ...