Total RNA from frozen tissues was extracted using TRIZOL reagent. RNA was extracted from formalin-fixed, paraffin-embedded tissues by digestion with proteinase K before the acid-phenol:chloroform ...
Alterations in the DNA methylome are characteristic for numerous diseases and a typical hallmark of cancer. Therefore, DNA methylation is currently under investigation in research labs and has also ...
As technologies and methodologies advance, so do the potential applications for biospecimens. In this article, we explore seven uses of FFPE, ranging from the common to the cutting-edge.
Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular diagnosis. However, due to RNA degradation and protein crosslinking, FFPE ...
N0234: Phase II study of erlotinib (OSI-774) plus gemcitabine as first-or second-line therapy for metastatic breast cancer (MBC) ...
An invaluable source of RNA, DNA, and chromatin from historical and clinical samples is formalin fixed paraffin embedded (FFPE) tissue. Globally, tissue banks, hospitals, and laboratories are ...
A single-arm trial of panitumumab in cetuximab refractory KRAS wild-type colorectal cancer. Background: Genomic profiling has improved our understanding of the underlying biology of tumors, accuracy ...
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