Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials have ...
Pediatric clinical trials commonly experience recruitment challenges including limited number of patients and investigators, inclusion/exclusion criteria that further reduce the patient pool, and a ...
SEER-Medicare data show just 4% of older adults with blood cancers enter clinical trials, revealing disparities and fixable ...
When trials include most of the patients in the target population, Sposto and Stram 23 investigated the relationship between type I error, sample size, trial duration, patient accrual rate, and ...
Background: Clinical trials do not represent community settings,making widespread implementation of evidence-based medicineproblematic. New heart failure treatments are an example, asresults ...
Drug development enterprise is struggling because of prohibitively high costs and slow progress. There is urgent need for adoption of novel adaptive designs to improve the efficiency and success of ...
Clinical trials that are embedded into usual care have the potential to yield outcomes of great relevance to the institutions where they are performed and at the same time to yield information that ...
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