Objective SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the ...

A first-in-human clinical trial evaluating an investigational gene therapy targeting complement-mediated pathways in ...

Anyone who has weathered a bad stomach bug knows the feeling: a loss of appetite that sets in and lingers, even after the ...

First patient dosed in Opti-GAIN, a first-in-human Phase I/II clinical trial of CTx001 in Geographic Atrophy secondary to AMD CTx001 is an investigational AAV-based gene therapy designed to deliver ...

Multi-omics profiling of residual cancer burden after neoadjuvant hormonal therapy guides subtype-directed treatment in high-risk and locally advanced prostate cancer. Predictive associations between ...

aDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China bDepartment of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that is also considered an autoimmune disorder. There is no single cure for C3G, but several treatments may slow disease progression, protect ...

A rare but severe stem cell transplant complication that often becomes fatal now has its first FDA-approved treatment, a therapy developed by biotechnology company Omeros. The Christmas Eve regulatory ...

Please provide your email address to receive an email when new articles are posted on . In the complex, multifactorial pathophysiology of glaucoma, as in most neurodegenerative diseases, inflammatory ...

Cedars-Sinai investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. Science X ...

The complement system is an innate immune response that leads to increased inflammation. The drug pegcetacoplan—a complement inhibitor—was approved for medical use in the United States in 2021 to ...