HBTU, DIPEA Peptide Coupling Mechanism | Organic Chemistry
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HBTU, DIPEA Peptide Coupling Mechanism | Organic Chemistry
The mechanism for a peptide coupling reaction which uses (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) as the coupling agent. The HBTU in this reaction works to create an active ester from the starting carboxylic acid. N,N-diisopropylethylamine (DIPEA) is used as the base to deprotonate the carboxylic acid ...
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